What Causes Increased Release of Noradrenaline During Heart Failure

Grant number: 1020783 | Funding period: 2012 - 2015

Completed

Abstract

Heart failure is associated with increased release of the neurotransmitter noradrenaline from sympathetic nerves to the heart and the kidney. The raised levels of this neurotransmitter in the heart and the kidney are harmful and lead to reduced survival in heart failure patients. This project will increase our understanding of the mechanisms that control noradrenaline release and may lead to better treatment paradigms to target the detrimental increase in release in heart failure.

Related publications (3)

Intrathecal Administration of Losartan Reduces Directly Recorded Cardiac Sympathetic Nerve Activity in Ovine Heart Failure

S Leversha, AM Allen, CN May, R Ramchandra

2019-10-01

Early and preferential activation of cardiac sympathetic nerve activity (CSNA) is one of the strongest prognostic markers of heart..

Neurohumoral interactions contributing to renal vasoconstriction and decreased renal blood flow in heart failure

R Ramchandra, DT Xing, M Matear, G Lambert, AM Allen, CN May

2019-09-01

In heart failure (HF), increases in renal sympathetic nerve activity (RSNA), renal norepinephrine spillover, and renin release cau..

Mechanisms underlying the increased cardiac norepinephrine spillover in heart failure

R Ramchandra, SG Hood, D Xing, GW Lambert, CN May

2018-08-01

Patients with heart failure (HF) have increased levels of cardiac norepinephrine (NE) spillover, which is an independent predictor..

University of Melbourne Researchers

Clive May